From personal use, not work so much, the extensions, plug-ins, and options make browsers behave differently and have problems. uBlock Origin is not liked by some sites that want to make me view ads. Decentraleyes seems to break quite a few sites. Turning off Java Script or cookies breaks lots of sites. Maybe Privacy Badger, CanvasFingerprintBlock, Tracking Token Stripper or others cause problems.
I feel for the IT folks that have to deal with all the possible variations in what could cause a problem. Not just the browser but everything someone can add or personalize.
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Regional Planetary Image Facility/Library
Lunar and Planetary Institute